It is possible, but you'll have to do a few things

.
1. get nircmd (
http://www.nirsoft.net/utils/nircmd.html).
2. Put the exe in your WINDOWS directory
3. find a PIF file. (There should be plenty in the windows dir. They have icons that say msdos and under the "type" column, they are listed as "shortcut to msdos")
4. copy the PIF to the windows dir and rename it to your choosing (i.e. opene).
5. Right click the PIF and go to properties
6. go to program tab.
7. in the cmd line box, type, without quotes, "cmd /k nircmd.exe cdrom open e:", where e is the target drive.
8. apply and exit.
9. create a keyword to that PIF
Hopefully you understood that. If not, feel free to ask!
BTW: there are many things that one can do with nircmd in this fashion, explore!