You may occasionally encounter the hotkey not working in Keybreeze Desktop. If you set focus to another application, it will start working again. This is typically caused by an application having administrative access in Windows, and the hotkey is not recognized within that application due to Windows security settings.
As an example, if you press Ctrl + Shift + Escape to open Task manager, or Start > Run > services.msc, the hotkey may stop working when these windows have focus.
A quick way to fix the issue is to press the Windows key on your keyboard, and then press the Keybreeze Desktop hotkey. Pressing the Windows key on your keyboard will shift the focus to the task bar, where the Keybreeze Desktop hotkey is recognized.
If you encounter this issue frequently, you can permanently fix it by running Keybreeze Desktop as an administrator. To do this, navigate to C:\Program Files (x86)\Keybreeze5 > right-click Keybreeze.exe and click Properties. Click the Compatibility tab, check 'Run this program as an administrator', and click OK. Close Keybreeze Desktop if it's currently running, and then reopen it. It will run as an administrator from this point forward, where the hotkey should work when any window has focus.
If you run Keybreeze Desktop at Windows startup, you may need to take additional steps.
There is an issue in Windows 10 where some applications will stop running at Windows startup if the 'Run this program as an administrator' checkbox is checked in the file properties. This behavior is documented in this StackExchange post -- https://superuser.com/questions/929225/how-to-run-a-program-as-an-administrator-at-startup-on-windows-10. Fortunately, there is a fix documented on this page:
When the window opens, right-click the background and click Paste. That should move the Keybreeze.vbs file from your Desktop to the Startup folder.
Once the above steps are completed, Keybreeze Desktop should run as an administrator whenever you restart your computer.